Coccidiosis has been a devastating disease which causes rapid mortality among poultry farms. The production of drugs used in the treatment of this disease condition helps a lot in the revival of poultry birds. This research work investigated the prevalence of coccidiosis and its treatment in some poultry farms in Ijebu East area of Ogun State, Nigeria using indigenous plant extract. Five poultry farms were used for the study. The results showed that coccidiosis was prevalent among the poultry birds and administration of pawpaw leaf extract resulted in significant cure of the birds. Phytochemical analysis of pawpaw leaf extract revealed the presence of phenol, flavonoids, alkaloids and tannin. Alkaloids were the highly predominant constituent in the pawpaw extract with 11.91% followed by flavonoid; percentages of phenol and tannin were not significant. Saponin was not detectable. The indigenous plants compared favourably with the standard anticoccidial drugs which are expensive and not easily available as shown in Table 2.