Production of large quantity of uniform growing seedlings is the desire of nursery men, while the quantity and quality of seedlings obtained are strongly influence by the composition of the media used. Therefore, studies on the effects of six media (GS, SD, 1:1 mixture of; GS+SD, GS+PD, SD+PD and 1:2:1 mixture of GS+PD+SD) on the germination of the seed and seedling development of Treculia africana var. africana were carried out. Potting media used strongly influenced variations in; the onset of seed germination, percentage seed germination responses and seedling growth performances. Generally, mixed media influenced early seed germination, higher percentage seed germination and better growth performances of the seedlings. The medium, 1:2:1 mixture of GS+PD+SD associated with the highest percentage water holding capacity and total nitrogen content, produced the highest percentage seed germination, 92:3%. The results suggest that the medium, 1:2:1 mixture of GS+PD+SD can be relied upon for routine propagation of the species, since it can assure for the production of large quantity of uniform seedlings necessary for the conservation and full exploitation of the species resources.